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by Michael Netzley Published July 29, 2025 in Brain Circuits • 3 min read • Audio available
a) most nights, b) sometimes, c) rarely.
a) very healthy, b) mixed, c) not healthy at all.
a) daily, b) sometimes, c) rarely or never.
a) rarely, b) often, c) most of the time.
a) daily, b) sometimes, c) rarely or never.
Mostly As: Congratulations – you are caring for your brain, enabling it to cope with uncertainty.
Mostly Bs: You’re doing some things well, some of the time – you just need to commit to a brain-healthy routine.
Mostly Cs: Your gray matter needs a rest! The following tips will give you the best chance of coping in uncertain times.
Uncertainty can activate the body’s sympathetic nervous system, triggering the brain’s fight, flight, or freeze response. Focused energy can create productive “flow states” for work that requires intense concentration in the short term. Most often, however, the stress response backfires, constricting thinking just when complexity and volatility demand broader cognitive capacity.
The alternative is to spend more time in the brain’s default mode, using the parasympathetic nervous system. This is a division of the autonomic nervous system responsible for conserving energy and maintaining restful bodily functions. Often called the “rest and digest” or “feed and breed” mode, it counteracts the fight or flight responses of the sympathetic nervous system: heart rate and breathing slow down, and the brain operates more widely, being comparatively open to possibility, diverse perspectives, and creative problem-solving – exactly the mindset needed for today’s world.
With the right habits, you can rewire your brain to more easily shift toward the parasympathetic system and unlock better decisions, creativity, and curiosity.
Your brain is an energy hog. Higher-order thinking – strategy, innovation, and judgment – consumes vast amounts of energy. To excel when uncertainty strikes, your brain needs energy reserves more than it needs resilience. The most effective way to boost brain energy is through better sleep, fitness, and nutrition. These three habits recharge your brain at night and fuel it during the day. Without this foundation, you’re far more likely to get stuck in a stress-triggered, narrow-minded state.
Begin shifting your brain out of fight-flight-freeze mode through breathing. Techniques like box breathing – or simply taking two sharp inhales followed by a long, slow exhale – signal safety to the brain and activate the parasympathetic system. Yoga and similar practices can offer additional breathing tools that help leaders stay calm and centered when facing uncertainty. Elite special forces and athletes use breathwork to great effect, and we should, too.
Mindfulness and meditation are powerful tools to build a brain that doesn’t immediately react to triggers. They help leaders stay present, maintain perspective, and welcome complexity instead of resisting it. Over time, mindfulness can rewire the brain to respond to uncertainty with more creativity, composure, and cognitive flexibility.
Every decision and judgment call you make begins in your brain. In a world of non-stop uncertainty, the leaders who thrive won’t be the ones who “fight, take flight, or freeze” – they’ll be the ones who respond with energy, openness, and clarity.Â

Founder of Extend My Runway
Dr Michael Netzley, PhD, is an entrepreneur, professor, and executive coach. He founded Extend My Runway (EMR) in 2018 to equip mid and late-career professionals with cutting-edge neuroscientific and behavioral insights.

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