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McKesson’s CEO Brian Tyler and other leaders have emphasized AI’s role in driving efficiency and growth. The company has strengthened its AI infrastructure through key partnerships and acquisitions, such as Ontada’s collaboration with Microsoft Azure OpenAI Service to apply large language models in oncology, and the acquisition of Compile to enhance data analytics. 

Internally, AI supports supply chain efficiency and customer service via inventory optimization and virtual assistants. Recognizing the human side of digital transformation, McKesson has introduced workforce training programs to build AI literacy and foster a digital mindset. 

In November 2024, the company updated its Code of Conduct specifically for artificial intelligence and its culture of innovation.