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Brain Circuits

Rewire your brain to turn challenge into opportunity

Published 4 March 2025 in Brain Circuits • 3 min read

The ability to flip negative signals in your brain into positive ones quickly is a transformative skill that turns challenges into opportunities. Dr. Estie Alessandrini explains how it’s done by asking yourself four simple questions in a cognitive reframing sequence.

The cognitive reframing sequence

This reinforces neural pathways linked to positive, solution-focused thinking by:

  • Promoting neuroplasticity (encouraging new thought patterns and perspectives on challenges).
  • Aligning with a growth mindset (viewing challenges as opportunities for development).
  • Engaging critical reflection (crucial for learning and personal growth).

How it’s done: four questions

When challenges arise, go through the following questions to transform them into opportunities:

1. So what?

First, take a step back and ask yourself, ‘So what?’ This encourages detachment from your initial emotional response and prompts critical thinking about the actual impact and significance of the challenge.

  • Benefit: allows you to gain perspective and reduces unnecessary stress.

2. Now what?

Now that your brain is in analytical-thinking mode, shift your focus to problem-solving and taking action. This engages your brain to seek solutions – a key aspect of a growth mindset.

  • Benefit: drives you towards positive change and proactive behaviour.

3. Then what?

This prompt encourages forward-thinking and a longer-term perspective. It helps you visualise potential outcomes and growth opportunities.

  • Benefit: enables you to plan strategically and anticipate future challenges.

4. But what if?

This question enhances the cognitive reframing process and incites innovative solutions. It facilitates ‘big-picture thinking’ by sparking creative thought processes and brainstorming to explore alternative scenarios and possibilities.

  • Benefit: amplifies potentially transformative outcomes and promotes a future-oriented, possibility-focused mindset.

Key learning

You can reshape your neural networks by habitually seeking opportunities in every challenge. Continually answering these questions will help you become a visionary leader who inspires innovation and creative problem-solving. Mastering this innovative aptitude is crucial for staying ahead in today’s dynamic business environment.

Authors

Estie Alessandrini

Dr. Estie Alessandrini is the creator of the Female Brain Advantage, and specialises in NeuroLeadership Development. She helps executives and entrepreneurs transform their unique brain strengths to lead with impact. With a background in clinical medicine, science and entrepreneurship, she innovatively translates brain science to drive individual growth, team excellence and organisational success. Estie offers individual and team leadership development programs, cognitive assessments, and high-impact workshops.

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